A study led by UCLA found that using MRI scans can distinguish between memory loss and brain trauma caused by Alzheimer’s disease.
Researchers at the University of California, Los Angeles and colleagues at Washington University in St. Louis say this finding is important because it can help prevent misdiagnosis of the devastating Alzheimer’s disease for patients and their families. A study found that as many as 21% of Alzheimer’s patients may be misdiagnosed as Alzheimer’s disease. Misdiagnosis may result in patients not receiving proper treatment and prevent them from participating in clinical trials that improve the overall level of care.
The study, currently published in the Journal of Alzheimer’s Disease, involved 40 UCLA patients with an average age of less than 68 years, who suffered a traumatic brain injury or TBI and later developed memory problems. According to data from the US Centers for Disease Control and Prevention, 2.87 million Americans experienced TBI in 2014, with the highest incidence among people 75 years of age or older. Children 4 and under and adults 65 and over are most likely to suffer severe brain damage after a fall.
Dr. Somayeh Meysami, postdoctoral fellow and lead author of the Cognitive and Behavioral Neurology of the David Geffen School of Medicine at the University of California, Los Angeles, said: “We already know that MRI can reveal the subtleties of patients with neurological diseases such as Alzheimer’s. Abnormalities.” “The purpose of our research is to assess whether MRI can also reveal obvious abnormalities in traumatic brain injury. Moreover, if we can recognize this pattern, it can improve the diagnosis of TBI-related memory loss in dementia caused by other causes. “
Research author Dr. Cyrus Raji said that by using software programs to analyze MRI scans, the study found that TBI caused the most damage to the brain region called the ventral midbrain, and the hippocampus atrophy was the least. Professor of Radiology at Washington University in St. Louis. The ventral forebrain is related to learning and emotion, while the hippocampus is related to memory and emotion. The hippocampus is also the brain area most affected by Alzheimer’s disease.
Dr. Raj said: “The method we use to measure the brain volume of these people is very useful because it can be applied to the same type of MRI scans we get in the clinic without the need for special types of imaging.” Alzheimer’s disease The association estimates that as many as 40% of dementias are caused by diseases other than Alzheimer’s disease.
He said: “Our research provides further evidence that not all memory loss is caused by Alzheimer’s disease.” Neurology, Psychiatry and Biology at the David Geffen School of Medicine at UCLA Dr. Mario Mendes, Professor of Behavioral Sciences, said: “It can be attributed to TBI and other dementia and neurodegenerative diseases.”